SS-31 30mg

SS-31 (Elamipretide) – 30mg – A Mitochondria-Targeting Peptide for Cellular Energy and Apoptosis Research

The SS-31 Elamipretide mitochondria-targeting peptide for research is a groundbreaking tool in the study of cellular bioenergetics. This product contains 30mg of high-purity, lyophilized powder, which researchers utilize to investigate oxidative stress and programmed cell death. As a novel, water-soluble tetra-peptide, it is specifically engineered to accumulate within the inner mitochondrial membrane. Consequently, it has become a foundational compound for experimental design in cardiology, neurology, and nephrology.

The Scientific Basis of SS-31’s Mechanism

The primary research value of the SS-31 Elamipretide mitochondria-targeting peptide for research lies in its ability to accumulate several hundred-fold within the site of ATP synthesis. Its mechanism focuses on two critical interactions:

• Cardiolipin Stabilization: It binds selectively to cardiolipin to stabilize the cristae structure. This prevents the release of pro-apoptotic factors like cytochrome c.

• ROS Scavenging: The dimethyltyrosine (Dmt) residue acts as a potent antioxidant. Specifically, it neutralizes free radicals at the electron transport chain before they cause lipid peroxidation.

• Metabolic Efficiency: By reducing proton leak, the peptide helps restore efficient coupling between electron transport and ATP production.

Key Research Applications

When applying the SS-31 Elamipretide mitochondria-targeting peptide for research in laboratory settings, several domains show significant promise. For instance, peer-reviewed studies highlight the following:

1. Ischemia-Reperfusion (IR) Injury: Research demonstrates that SS-31 prevents the mitochondrial permeability transition pore (mPTP) from opening during reoxygenation.

2. Age-Related Dysfunction: Scientists use this peptide to test the mitochondrial free radical theory of aging by mitigating DNA and protein damage.

3. Cardiomyopathy Models: Because the heart is metabolically active, this peptide is essential for investigating contractility and calcium handling in heart failure models.

Recommended Research Protocols

For successful in-vitro replication, the SS-31 Elamipretide mitochondria-targeting peptide for research requires precise dosing. Effective concentrations in cell culture typically range from 1 nM to 100 nM.

Quality Assurance and Handling

At EliteBiogenix, we guarantee $\ge$98% purity for our SS-31 Elamipretide mitochondria-targeting peptide for research. To maintain stability, you must store the lyophilized powder at -20°C and protect it from light. Furthermore, while the peptide is highly soluble in water or sterile saline, we recommend preparing fresh solutions for each experiment to ensure maximum potency.