CJC 1295 NO DAC 5mg

A Precise Tool for Pulsatile GH Research

Researchers utilize CJC-1295 No DAC, also known as Modified GRF 1-29, to investigate the intricate dynamics of the hypothalamic-pituitary axis. This synthetic analog of Growth Hormone-Releasing Hormone (GHRH) is specifically engineered for enhanced stability and receptor binding. Specifically, it lacks the Drug Affinity Complex (DAC) moiety, which allows for the study of natural, pulsatile growth hormone (GH) release patterns. Consequently, scientists can explore physiological-like secretory bursts without the sustained elevation associated with long-acting versions.

Mechanisms of GHRH Receptor Agonism

The primary research value of this peptide lies in its potent agonism of the GHRH receptor located on pituitary somatotroph cells. Upon binding to these receptors, the compound initiates a signaling cascade involving cyclic AMP (cAMP) and protein kinase A (PKA). Moreover, this process triggers the synthesis and secretion of growth hormone from cellular storage vesicles. Therefore, the peptide serves as a critical instrument for measuring intracellular signaling and gene expression within immortalized somatotroph cell lines.

Enhanced Stability Through Structural Modification

This tetra-substituted analog incorporates specific amino acid modifications to resist enzymatic degradation by dipeptidyl peptidase-4 (DPP-4). Notably, substituting the first two amino acids with D-Ala significantly extends the peptide’s half-life compared to native GHRH (1-29). Similarly, these modifications ensure that the compound remains active long enough for thorough in-vitro analysis. Thus, researchers achieve more reliable and reproducible data during dose-response and time-course studies in laboratory settings.

Comparative Metabolic and Synergistic Studies

In addition, CJC-1295 No DAC is a vital comparator for studying the metabolic effects of discrete GH pulses versus continuous exposure. Researchers often combine this GHRH analog with ghrelin agonists, such as Ipamorelin or GHRP-2, to investigate synergistic secretory responses. Specifically, these experiments help dissect the balance of the growth hormone axis when influenced by opposing signals like somatostatin. Consequently, the compound provides essential insights into hepatocyte IGF-1 production and adipocyte lipolytic activity.

EliteBiogenix Quality and Technical Specifications

Finally, every vial of CJC-1295 No DAC from EliteBiogenix undergoes rigorous HPLC verification to ensure a purity level of $\ge$ 98%. This high standard ensures that experimental results are directly attributable to the peptide sequence rather than chemical impurities.

• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂

• Purity: $\ge$ 98% (HPLC Verified).

• Storage: Store at -20°C or below; protect from light and desiccate.

• Solubility: Soluble in sterile water or bacteriostatic water for precise volumetric dosing.

• Compliance: Strictly for in-vitro laboratory research; not for human or veterinary use.